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Acmoxanthones A-E, New Lavandulated Xanthones from Hypericum acmosepalum N. Robson
Ai-Zhu Wang1, Qiang-Qiang Fang2, Tong-Tong Feng3
1School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610000, China; Natural Product Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Abstract:
Acmoxanthones A-E (1-5), five new lavandulylated xanthones, were isolated from the aerial parts of Hypericum acmosepalum, together with four known xanthones. Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR and chiroptical properties. A bioassay against high glucose-induced damage on human umbilical vein endothelial cells (HUVECs) showed ananixanthone (6) and osajaxanthone (7) had potential antioxidative damage activity with EC50 values of 10.5 μg/mL and 7.6 μg/mL, respectively, while 3-hydroxy-2,4-dimethoxyxanthone (8) exhibited cytotoxic effect on the damaged cells with IC50 values of 7.1 μg/mL.
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