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Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

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Updated: Nov 5, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Lateralization bias for autoimmune optic neuritis.

Yavor Yalachkov¹, Svenja Klinsing¹, Christian Foerch¹

¹Department of Neurology, University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Multiple Sclerosis and Related Disorders

|May 13, 2021

Summary

This summary is machine-generated.

Autoimmune optic neuritis (aON) more often affects the left eye than the right. People also search online more frequently for left-sided aON symptoms, suggesting a potential leftward bias in this neurological condition.

Keywords:

Autoimmune optic neuritis Lateralization Multiple sclerosis, Neuromyelitis optica spectrum disorder Sarcoidosis

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Published on: November 12, 2020

Area of Science:

Neurology
Neuroimmunology
Ophthalmology

Background:

Human brain exhibits structural asymmetry and lateralization in neurological diseases.
Autoimmune optic neuritis (aON) is a neurological condition affecting the optic nerve.

Purpose of the Study:

To investigate if unilateral aON presents more frequently in the left eye compared to the right.
To determine if online searches for aON symptoms reflect a similar leftward bias.

Main Methods:

Retrospective analysis of 552 unilateral aON cases and 374 MRI scans (2009-2019).
Analysis of Google searches for aON symptoms in Germany, US, and UK using Searchmetrics Suite.
Comparison of left vs. right eye aON manifestation frequency and MRI findings.
Assessment of Google search trends for left vs. right eye aON symptoms.

Main Results:

Left eye aON manifestations occurred more frequently (55.3%) than right eye (44.7%) (p=0.015).
Left eye aON was 1.9 times more likely to show pathological MRI findings (p=0.013).
Google searches for left-sided aON symptoms were significantly more frequent than for right-sided symptoms (p < 0.001).

Conclusions:

Autoimmune optic neuritis demonstrates a leftward lateralization bias, affecting the left eye more often.
This bias is reflected in both clinical presentation and online search behavior.
Findings suggest a neurological lateralization similar to that observed in cerebral neuroinflammatory lesions.