Effects of regular whey protein consumption on rat thyroid functions

Area of Science:

• Endocrinology
• Nutrition Science
• Biochemistry

Background:

• Thyroid hormones (TSH, T3, T4) regulate metabolism.
• Whey protein is a rich source of amino acids.
• The impact of isolated hydrolyzed whey protein (IHWP) on thyroid function requires investigation.

Purpose of the Study:

• To determine the effect of different doses of IHWP on thyroid hormone levels (TSH, T4).
• To evaluate histopathological changes in thyroid tissues after IHWP administration.
• To assess the relationship between IHWP intake and thyroid hormone synthesis.

Main Methods:

• 24 rats were divided into three groups: control (standard feed), low-dose IHWP (0.3 g/kg), and high-dose IHWP (0.5 g/kg) for 12 weeks.
• Blood samples were collected pre- and post-administration for hormone analysis.
• Thyroid tissues were examined histopathologically.

Main Results:

• Rats receiving IHWP showed significantly higher thyroid hormone T4 levels compared to the control group.
• Thyroid hormone synthesis parameters (colloid amount, follicular diameter, epithelial height) were elevated in IHWP-treated rats.
• Interfollicular connective tissue and TSH levels were higher in the control group.

Conclusions:

• Regular daily intake of IHWP may enhance thyroid hormone synthesis.
• The high amino acid content of IHWP is a potential mechanism for increased thyroid hormone production.
• IHWP shows potential as a dietary supplement influencing thyroid function.