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Imaging Biological Samples with Optical Microscopy01:18

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Two-step training deep learning framework for computational imaging without physics priors.

Ruibo Shang, Kevin Hoffer-Hawlik, Fei Wang

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    A novel two-step training deep learning (DL) framework reconstructs images without physics priors. This method improves robustness to model errors and noise, outperforming traditional DL approaches for computational imaging.

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    Area of Science:

    • Computational imaging
    • Deep learning applications
    • Image reconstruction

    Background:

    • Deep learning (DL) is vital in computational imaging, often using preprocessors with physics priors.
    • Model mismatches and network over-parameterization pose challenges in DL-based image reconstruction.
    • Ill-posed inverse problems in imaging can lead to suboptimal DL performance.

    Purpose of the Study:

    • To propose a two-step training deep learning (TST-DL) framework for computational imaging that bypasses the need for physics priors.
    • To address challenges of model mismatch and network over-parameterization in image reconstruction.
    • To develop a flexible and robust DL approach for diverse computational imaging systems.

    Main Methods:

    • A two-step training DL (TST-DL) framework was developed.
    • The first step involves training a fully-connected layer (FCL) to learn the inverse model directly from raw measurement data.
    • The second step concatenates the pre-trained FCL with an untrained U-Net architecture for image optimization.

    Main Results:

    • The TST-DL framework demonstrated performance comparable to methods using perfect physics knowledge.
    • It showed robustness to noise, model ill-posedness, and model mismatch.
    • TST-DL outperformed end-to-end training with less overfitting and better results than approaches with imperfect physics knowledge.

    Conclusions:

    • The TST-DL framework offers a flexible approach to image reconstruction without requiring explicit physics priors.
    • This method effectively mitigates issues related to model mismatch and network over-parameterization.
    • TST-DL is a promising technique for various computational imaging applications.