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Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of ACE2 and

Mălina Suciu-Petrescu1,2, Anamaria Truta3, Mihai Domnutiu Suciu4

  • 1Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.

Experimental and Therapeutic Medicine
|May 14, 2021
PubMed

Insights

Genetic variations in ACE2 and MCP-1 genes are linked to cardiac remodeling in heart failure patients. Specific single nucleotide polymorphisms (SNPs) correlate with left ventricle and left atrial changes, impacting heart function.

Area of Science:

  • Cardiovascular Genetics
  • Translational Research
  • Molecular Cardiology

Background:

  • Heart failure (HF) is a primary cause of hospitalization in older adults, stemming from environmental and genetic factors.
  • Cardiac remodeling, including left ventricular hypertrophy (LVH) and chamber dilatation, is a key pathological process in HF.
  • Understanding the genetic underpinnings of HF and cardiac remodeling is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the angiotensin converting enzyme 2 (ACE2) and monocyte chemoattractant protein-1 (MCP-1) genes and cardiac remodeling.
  • To evaluate specific ACE2 SNPs (rs4646156, rs4646174) and MCP-1 SNP (rs1024611) in Caucasian heart failure patients.
  • To correlate genetic variants with echocardiographic parameters of cardiac structure and function.

Main Methods:

  • Comparative translational research study involving 116 Caucasian heart failure patients.
  • Genotyping of ACE2 SNPs (rs4646156, rs4646174) and MCP-1 SNP (rs1024611) using Taqman real-time PCR.
  • Analysis of echocardiographic data to assess cardiac remodeling parameters like left ventricle dimensions, left atrial size, and ejection fraction.

Main Results:

  • Carriers of the AA genotype for ACE2 rs4646156 showed significant left ventricle dilatation and LVH.
  • TT carriers of ACE2 rs4646156 exhibited significant left atrial dilatation.
  • Homozygotes for the C allele of ACE2 rs4646174 presented with dilated LV, LVH, and a trend towards lower ejection fraction.
  • MCP-1 rs1024611 AA variant carriers demonstrated significant LVH.

Conclusions:

  • Specific SNPs in ACE2 (rs4646156, rs4646174) and MCP-1 (rs1024611) are strongly associated with cardiac remodeling in heart failure.
  • These genetic variants may serve as biomarkers for predicting cardiac structural changes in HF patients.
  • Further research can explore the functional mechanisms linking these SNPs to HF pathophysiology.

Keywords:
ACE2 polymorphismMCP-1 polymorphismechocardiographyheart failurers1024611rs4646156rs4646174

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