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Role of ARK5 in cancer and other diseases (Review)

Guoheng Mo1, Bohan Zhang2, Qunguang Jiang3

  • 1Department of Neurosurgery, Queen Mary College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Experimental and Therapeutic Medicine
|May 14, 2021
PubMed

Insights

AMP-activated protein kinase-related protein kinase 5 (ARK5) is crucial in cancer, regulating metabolism and metastasis. Targeting ARK5 may enhance cancer treatment efficacy and address other diseases like neurodegeneration.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Malignant tumors create hypoxic and glucose-starved microenvironments.
  • AMP-activated protein kinase (AMPK) is an energy sensor vital for cellular metabolism and protection against hypoxic injury.
  • AMPK-related protein kinase 5 (ARK5), an AMPK family member, plays a key role in energy regulation and hypoxia.

Purpose of the Study:

  • To review the upstream and downstream molecular pathways of ARK5 in cancer and other diseases.
  • To discuss potential therapeutic strategies targeting ARK5.

Main Methods:

  • Literature review of studies on ARK5 function and regulation.
  • Analysis of ARK5's role in cancer invasion, metastasis, and drug sensitivity.
  • Exploration of ARK5's involvement in non-cancerous conditions.

Main Results:

  • ARK5 is overexpressed in invasive and metastatic cancers, correlating with malignancy.
  • ARK5 downregulation enhances drug sensitivity via the epithelial-mesenchymal transition pathway.
  • ARK5 is implicated in neurodegenerative diseases, renal disorders, and muscle generation.

Conclusions:

  • ARK5 is a potential therapeutic target for cancer treatment.
  • Understanding ARK5 pathways can inform strategies for various diseases.
  • ARK5's multifaceted roles highlight its significance in cellular energy homeostasis and disease pathology.
Keywords:
AMP-activated protein kinase-related protein kinase 5AMP-activated protein kinase-related protein kinase 5-associated diseasescancerpotential therapeutic strategiestumor metastasis

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