Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic Target

Together with nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H₂S) is now recognized as a vital gaseous transmitter. The ubiquitous distributions of H₂S-producing enzymes and potent chemical reactivities of H₂S in biological systems make H₂S unique in its ability to regulate cellular and organ functions in both health and disease. Acting as an antioxidant, H₂S can combat oxidative species such as reactive oxygen species (ROS) and reactive nitrogen species (RNS) and protect the skin from oxidative stress. The aberrant metabolism of H₂S is involved in the pathogenesis of several skin diseases, such as vascular disorders, psoriasis, ulcers, pigment disorders, and melanoma. Furthermore, H₂S donors and some H₂S hybrids have been evaluated in many experimental models of human disease and have shown promising therapeutic results. In this review, we discuss recent advances in understanding H₂S and its antioxidant effects on skin pathology, the roles of altered H₂S metabolism in skin disorders, and the potential value of H₂S as a therapeutic intervention in skin diseases.