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Lenalidomide-Associated Hemophagocytic Lymphohistiocytosis With Plasma Cell Phagocytosis

Elliot Runge1, Chung-Ting J Kou1, Matthew Rendo2

  • 1Internal Medicine, Brooke Army Medical Center, San Antonio, USA.

Cureus
|May 14, 2021
PubMed

Hemophagocytic lymphohistiocytosis (HLH) is a severe systemic inflammatory syndrome that is often fatal. In the adult population, it is believed to develop secondary to immune dysregulation due to rheumatologic, infectious, malignant, and recently, immunomodulatory drugs. It's co-occurrence with phagocytosis by non-macrophage cells has not been previously well defined. We present a case of lenalidomide-associated HLH with concurrent plasma cell hemophagocytosis in a patient with controlled multiple myeloma (MM).

Keywords:
diagnosis of multiple myelomahemophagocytic lymphohistiocytosis (hlh)lenalidomidesecondary hlh

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