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Updated: Nov 5, 2025

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Published on: March 11, 2021
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP
Lin-Hua Jiang1, Emily A Caseley2,3, Steve P Muench2
1School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK. l.h.jiang@leeds.ac.uk.
Abstract:
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction with site-directed mutagenesis, molecular modelling, and, recently, structural determination, have provided significant insights into the structure-function relationships of the P2X7 receptor. This review discusses the current understanding of the structural basis for the functional properties of the P2X7 receptor.
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