Related Experiment Video
Updated: Nov 5, 2025
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
Published on: December 15, 2010
Surface Wettability of Nanoparticle Modulated Sonothrombolysis
Qingyuan Wu1, Fengrong Zhang1, Xueting Pan1
1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Sonodynamic therapy (SDT) effectiveness is enhanced by nanoparticle wettability, which stabilizes nanobubbles. Nanoparticles with optimal wettability improve thrombolytic efficiency in rat models, advancing SDT applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Acoustic Medicine
Background:
- Sonodynamic therapy (SDT) is a promising non-invasive treatment utilizing ultrasound irradiation.
- The precise mechanism underlying SDT efficacy, particularly how nanoparticles enhance it, remains unclear, limiting clinical translation.
- Nanoparticle-stabilized nanobubbles are proposed to play a crucial role in SDT enhancement.
Purpose of the Study:
- To investigate the mechanism of SDT enhancement mediated by nanoparticle wettability.
- To determine the relationship between nanoparticle wettability, nanobubble stability, and SDT efficiency.
- To guide the rational design of nanoparticles for improved SDT outcomes.
Main Methods:
- Investigated the adsorption and stabilization of nanobubbles by various nanoparticles (mesoporous silica, polystyrene).
- Correlated nanobubble stability with nanoparticle desorption energy, determined by water contact angle (wettability).
- Evaluated thrombolytic efficiency of nanoparticles with varying wettability in a rat thrombus model.
Main Results:
- Nanoparticle wettability directly influences nanobubble stability and SDT enhancement.
- Optimal nanoparticle desorption energy, achieved with a water contact angle around 90°, maximizes nanobubble stability.
- Nanoparticles with the highest desorption energy demonstrated superior thrombolytic efficiency in vivo.
Conclusions:
- Nanoparticle wettability is a critical factor for enhancing sonodynamic therapy efficacy through nanobubble stabilization.
- Nanoparticles with a water contact angle of approximately 90° exhibit optimal properties for SDT.
- These findings provide a mechanistic understanding of SDT and a strategy for designing improved nanoparticles for clinical use.
