Related Experiment Video
Updated: Nov 5, 2025
17:06
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
26.6K
Characterization of Brain Microstructural Abnormalities in High Myopia Patients: A Preliminary Diffusion Kurtosis
Huihui Wang1, Hongwei Wen2, Jing Li1
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Korean Journal of Radiology
|May 14, 2021
Summary
Diffusion kurtosis imaging (DKI) reveals white matter damage in high myopia (HM) patients. Microstructural alterations correlate with disease duration, suggesting DKI
Area of Science:
- Neuroimaging
- Ophthalmology
- Radiology
Background:
- High myopia (HM) is associated with potential neurological complications.
- Understanding white matter integrity in HM is crucial for disease management.
Purpose of the Study:
- To evaluate microstructural brain damage in high myopia (HM) patients using 3T diffusion kurtosis imaging (DKI).
- To assess the relationship between microstructural changes and disease duration in HM.
Main Methods:
- Prospective study comparing 30 HM patients and 33 healthy controls (HCs).
- Acquired DKI parameters: kurtosis (FA, MK, AK, RK) and diffusion (FA, MD, AD, RD).
- Analyzed group differences using tract-based spatial statistics and partial correlation.
Main Results:
- HM patients exhibited reduced axial kurtosis (AK), radial kurtosis (RK), mean kurtosis (MK), and fractional anisotropy (FA).
- HM patients showed increased axial diffusivity (AD) in specific white matter tracts and the thalamus.
- Kurtosis parameters negatively correlated with disease duration, while AD positively correlated.
Conclusions:
- HM patients demonstrate white matter microstructural alterations in motor and visual pathways.
- DKI is effective in detecting white matter abnormalities in HM.
- DKI may aid in monitoring HM pathogenesis.
