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[Focal lesions in infantile spasms]
1Service de neuropédiatrie, INSERM U-29, Hôpital Saint-Vincent-de-Paul, Paris, France.
Neurophysiologie Clinique = Clinical Neurophysiology
|June 1, 1988
Summary
Focal brain lesions, particularly in the rolandic and temporo-occipital areas, are linked to infantile spasms. Frontal lobe involvement may predict later partial epilepsy.
Area of Science:
- Neurology
- Pediatric Neurology
- Neuroradiology
Context:
- Infantile spasms (IS) are a severe epilepsy syndrome in infants.
- Focal brain lesions can cause neurological disorders.
- CT scans were used to evaluate brain structure in infants with IS.
Purpose:
- To investigate the characteristics of focal brain lesions in infants with infantile spasms.
- To determine the relationship between lesion location and epilepsy recurrence.
Summary:
- Out of 174 infants with infantile spasms, 17 (9.8%) had focal lesions without microcephaly.
- These lesions included angioma, cortical dysplasia, and porencephaly, often resulting from early life events.
- Lesions predominantly affected the rolandic and temporo-occipital regions, with frontal lobe involvement associated with later partial epilepsy recurrence after steroid treatment.
Impact:
- Identifies specific brain regions associated with infantile spasms.
- Suggests that lesion location influences the type and prognosis of epilepsy.
- Provides insights into the neuroanatomical basis of infantile spasms and subsequent epilepsy.