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Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
Published on: November 4, 2016
Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Series and Review
Ather Adnan1, Priscilla R Powell, Cecil Jordan Staples
1Medical Student, College of Medicine, Texas A&M Health Science Center, Houston, TX; Resident Physician, Department of Pathology, Baylor Scott and White Medical Center, Temple, TX; Intern, Department of Internal Medicine, University of Texas Austin Dell Medical School, Austin, TX; Clinical Assistant Professor, Department of Dermatology, Baylor Scott and White Medical Center, Temple, TX; and Clinical Associate Professor, Department of Dermatology and Pathology, Baylor Scott and White Medical Center, Temple, TX.
Abstract:
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy that frequently has cutaneous manifestations. The diagnosis can be a challenge because of its heterogenous clinical presentation, ranging from a brown or violaceous solitary nodule or patch to mixed, disseminated lesions. Furthermore, BPDCN tumor cells express immunohistochemical markers in common with acute myeloid leukemia, which can lead to misdiagnosis. Timely diagnosis requires awareness of its cutaneous manifestations and unique histopathology and immunophenotype. We present a case series of patients diagnosed with BPDCN and review the cutaneous and histopathologic characteristics of this uncommon entity.
