Phosphonate/zwitterionic/cationic terpolymers as high-efficiency bactericidal and antifouling coatings for metallic
Xiao Zhang1, Li Liu1, Wan Peng1
1Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China. 07264@njnu.edu.cn liups@njnu.edu.cn.
Journal of Materials Chemistry. B
|May 14, 2021
Summary
New phosphonate/zwitterionic/quaternary amine terpolymers offer advanced antifouling and bactericidal coatings for metallic implants. These coatings effectively combat bacterial infections on medical devices, enhancing patient safety.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Chemistry
Background:
- Bacterial infections pose a significant challenge for metallic implants and biomedical devices.
- Developing effective antimicrobial coatings is crucial for preventing implant-associated infections.
Purpose of the Study:
- To synthesize and characterize novel phosphonate/zwitterionic/quaternary amine terpolymers.
- To evaluate the antifouling and bactericidal properties of these terpolymers as coatings for metallic substrates.
- To investigate the impact of varying zwitterionic and cationic content on coating performance.
Main Methods:
- Reversible-addition fragmentation chain transfer (RAFT) polymerization and quaternization were used to synthesize terpolymers.
- Terpolymers were coated onto TC4 metallic substrates via phosphonate group coordination.
- Water contact angle and X-ray photoelectron spectroscopy (XPS) were employed for surface characterization.
- Bactericidal assays were performed using Staphylococcus aureus and Escherichia coli.
Main Results:
- Well-controlled terpolymers with tunable zwitterionic and cationic segments were synthesized.
- The phosphonate groups facilitated strong adhesion of the polymer coatings to metallic substrates.
- Antibacterial efficiency increased with higher cationic content, reaching over 97% bacterial kill for specific compositions.
- The dual-functional coatings demonstrated excellent antifouling and bactericidal properties, with up to 99.5% bacterial reduction.
- The coatings showed broad applicability to various metallic substrates like titanium, stainless steel, and Ni/Cr alloy.
Conclusions:
- Phosphonate/zwitterionic/quaternary amine terpolymers provide a highly effective strategy for creating antifouling and bactericidal surfaces on metallic implants.
- These dual-functional coatings significantly reduce bacterial adhesion and proliferation, addressing a critical need in biomedical applications.
- The developed coating technology offers a promising approach to prevent bacterial infections associated with metallic medical devices.
Related Concept Videos
01:22Waterproofing and Anti-Bacterial Admixtures in Concrete
134
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...
134
01:29Biofilms
589
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
589
01:27Chemical Agents for Microbial Control
502
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
502