Update on brain MRI for the diagnosis and follow-up of MS patients

Area of Science:

• Neurology
• Radiology
• Medical Imaging

Background:

• Magnetic Resonance Imaging (MRI) is a cornerstone in diagnosing and monitoring multiple sclerosis (MS).
• International recommendations emphasize standardized neurological and radiological practices.
• Concerns regarding gadolinium deposition from contrast agents have emerged, prompting regulatory warnings.

Purpose of the Study:

• To review the French MS registry's recommendations for MRI contrast agent use.
• To inform neurologists about updated imaging protocols for MS management.
• To highlight the benefits of standardized imaging in clinical practice and advanced technique development.

Main Methods:

• Analysis of recommendations from the "Observatoire français de la sclérose en plaques" (French MS registry).
• Incorporation of findings from a national consultation involving neurologists and neuroradiologists.
• Publication of guidelines based on the precautionary principle regarding gadolinium-based contrast agents.

Main Results:

• A national recommendation was issued in early 2020, limiting contrast agent injections.
• The precautionary principle guides the administration of limited contrast product quantities.
• No clinically harmful manifestations of gadolinium deposition have been detected to date.

Conclusions:

• Updated MRI protocols aim to improve the management of MS patients.
• Standardized imaging practices enhance clinical utility and support advanced technique development.
• Neurologists are encouraged to adopt these imaging protocols for optimal patient care and therapeutic monitoring.