[Changes in the morphometric parameters of neuroblastoma cells cultured at an elevated pH]

The phenomena arising during morphological differentiation of neuroblastoma cells under pH of culture medium 8.0-8.2 have been investigated. The initial cell population divided into two parts--proliferating and differentiating cells--on the third day of cultivation in the modified medium. Reliable correlation between somatic size and neurite length has been found in differentiating cells. Thus somatic size may be used as morphological criterion of differentiated neuroblastoma cells under present conditions. The established relations may be used for the further investigation of morphofunctional alterations under induced differentiation of neuroblastoma cells.