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Updated: Nov 5, 2025

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Foot ischemia related to essential thrombocytemia and atherosclerosis
F Legrand1, A Fernex de Mongex1, M Delrue2
1Vascular medicine department, GH Paris Saint-Joseph, Paris, France.
Abstract:
We report two cases of foot ischemia combining microvascular thrombosis related to essential thrombocytemia (ET) and a proximal ulcerating atherosclerotic plaque. This suggests that myeloproliferative neoplasms could also trigger distal embolism from an unstable atherosclerotic plaque by creating a prothrombotic status. These distal ischemic events were the first ET manifestation and therefore lead to myeloproliferative neoplasm diagnosis. In ET, thrombosis event can occur with a normal platelet count. Furthermore, hemogram should be regularly controlled among JAK2 muted patients considering the frequent evolution from isolated JAK2 mutation to ET.
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