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Updated: Nov 5, 2025

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
Published on: August 16, 2012
Neutron tomography of Van Leeuwenhoek's microscopes
Tiemen Cocquyt1, Zhou Zhou2, Jeroen Plomp2
1Rijksmuseum Boerhaave, Lange Sint Agnietenstraat 10, Leiden, Netherlands. tiemencocquyt@rijksmuseumboerhaave.nl.
Abstract:
The technique of neutron tomography has, after 350 years, enabled a first look inside the iconic single-lens microscopes of Antoni van Leeuwenhoek. Van Leeuwenhoek's 17th-century discovery of "animalcules" marks the birth of microbiology. His skillfully self-produced microscope lenses remained unsurpassed for over 150 years. Neutron tomography now enabled us to reveal the lens types Van Leeuwenhoek used. We argue that Van Leeuwenhoek's instruments incorporate some innovations that testify to an awareness of concurrent developments. In particular, our analysis shows that for making his best-performing microscopes, Van Leeuwenhoek deployed a lens-making procedure popularized in 1678 by Robert Hooke. This is notable, as Hooke always wanted to find the secret of Van Leeuwenhoek's lenses, but never managed to do so. Therefore, Van Leeuwenhoek was far from the isolated scholar he is often claimed to be; rather, his secrecy about his lenses was motivated by an attempt to conceal his indebtedness to Hooke.
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