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Updated: Nov 5, 2025

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
Published on: May 22, 2019
Depression after stroke
João Facucho-Oliveira1, Daniel Esteves-Sousa2, Pedro Espada-Santos2
1Department of Mental Health and Psychiatry, Lusiadas Health Group, Lisboa, Portugal Jmfacuchoo@hotmail.com.
Abstract:
Stroke treatment has dramatically improved in recent decades. However, although new treatments have reduced its mortality and the severity of its physical and cognitive sequelae, many people still have incapacitating disabilities following a stroke. Depression is the most common psychiatric disorder following stroke; it is important to recognise and treat as it limits motor and cognitive rehabilitation. Antidepressant medication is an effective treatment and can improve adherence to clinically recommended physical and cognitive tasks, thereby enhancing functional remodelling of neuronal pathways and improving rehabilitation outcomes.
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