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Updated: Nov 5, 2025

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
Neuromuscular Ultrasound: Indications in the Electrodiagnostic Laboratory
Shawn P Jorgensen1, Michael S Cartwright, John Norbury
1From the Department of Physical Medicine and Rehabilitation, Albany Medical College, Albany, New York (SPJ); Department of Family Medicine, Larner Medical College at the University of Vermont, Burlington, Vermont (SPJ); Adirondack Rehabilitation Medicine, PLLC, Queensbury, New York (SPJ); Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina (MSC); and Division of Physical Medicine and Rehabilitation, Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, Texas (JN).
Neuromuscular ultrasound is a valuable tool for diagnosing nerve disorders like carpal tunnel syndrome and ulnar neuropathy. It aids in cases with unclear electrodiagnostic study results and identifies nerve damage causes.
Area of Science:
- Neurology
- Diagnostic Imaging
Background:
- Accurate assessment of neuromuscular disorders is crucial for effective treatment and patient outcomes.
- Electrodiagnostic studies have traditionally been the standard for diagnosis.
- Neuromuscular ultrasound is emerging as a key diagnostic tool in electrodiagnostic laboratories.
Purpose of the Study:
- To review the evidence-based applications of neuromuscular ultrasound in electrodiagnostic laboratories.
- To highlight uses suitable for typical laboratories with standard equipment and training.
- To discuss the evolving role of neuromuscular ultrasound in clinical practice.
Main Methods:
- Review of current literature and evidence supporting neuromuscular ultrasound applications.
- Focus on diagnostic accuracy for specific neuropathies.
- Emphasis on practical implementation in electrodiagnostic settings.
Main Results:
- Strong evidence supports neuromuscular ultrasound for diagnosing carpal tunnel syndrome and ulnar neuropathies.
- It serves as a supplementary test for equivocal electrodiagnostic studies and nonlocalizing axonal lesions.
- Ultrasound identifies causes of focal mononeuropathies, potentially altering treatment.
- It is sensitive for detecting fasciculations and supporting diagnoses of autoimmune demyelinating polyneuropathies.
- Assessment of nerves post-trauma is a significant application.
Conclusions:
- Neuromuscular ultrasound offers strong evidence-based applications for common neuropathies.
- Its utility extends to complex cases and trauma assessment.
- Continued technological advancements promise to expand its role in electrodiagnostic laboratories.
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