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Aggrecan: a new biomarker for acute type A aortic dissection
Karl C König1, Harald Lahm2, Martina Dreßen3
1Division of Experimental Surgery, Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Lazarettstrasse 36, 80636, Munich, Germany. koenigc@dhm.mhn.de.
Scientific Reports
|May 15, 2021
Summary
Aggrecan (ACAN) shows promise as a biomarker for diagnosing acute type A aortic dissection (ATAAD). Elevated ACAN plasma levels can help identify patients needing urgent surgical intervention for this life-threatening condition.
Area of Science:
- Cardiovascular Research
- Biomarker Discovery
- Aortic Pathology
Background:
- Acute type A aortic dissection (ATAAD) is a critical condition with high mortality.
- Early diagnosis is crucial for timely intervention and improved patient outcomes.
- Previous studies indicated elevated aggrecan (ACAN) mRNA in ATAAD tissues.
Purpose of the Study:
- To investigate aggrecan (ACAN) as a potential plasma biomarker for ATAAD diagnosis.
- To evaluate the diagnostic accuracy of ACAN in distinguishing ATAAD from other conditions.
Main Methods:
- Measured plasma ACAN protein concentrations in ATAAD patients, thoracic aortic aneurysm patients, myocardial infarction patients, and healthy volunteers.
- Utilized receiver-operator characteristic (ROC) curve analysis to determine diagnostic performance.
- Assessed correlation between ACAN levels and cardiac enzymes.
Main Results:
- Plasma ACAN concentration was significantly higher in ATAAD patients (38.59 ng/mL) compared to controls.
- Optimal discrimination limit for ATAAD was 14.3 ng/mL, with 97% sensitivity and 81% specificity.
- No correlation was found between ACAN levels and cardiac enzymes in ATAAD patients.
Conclusions:
- Aggrecan (ACAN) is a reliable potential biomarker in plasma for the diagnosis of ATAAD.
- ACAN demonstrates high sensitivity and specificity for detecting ATAAD.
- This finding supports ACAN's utility in clinical settings for early ATAAD identification.
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