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Low LDL-C levels are associated with risk of mortality in a Chinese cohort study

Jie-Ming Lu1, Meng-Yin Wu1, Zong-Ming Yang1

  • 1Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Zhejiang, 310058, Hangzhou, China.

Endocrine
|May 15, 2021
PubMed

Insights

Extremely low low-density lipoprotein cholesterol (LDL-C) levels are linked to higher mortality risks, including cardiovascular disease and cancer, in the Chinese population. This finding highlights the importance of considering LDL-C in overall health assessments.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Low-density lipoprotein cholesterol (LDL-C) is a known risk factor for atherosclerotic cardiovascular disease.
  • Limited research exists on the association between LDL-C levels and mortality risk in the general population.

Purpose of the Study:

  • To investigate the association between LDL-C levels and the risk of all-cause and cause-specific mortality.
  • To analyze this association in a large Chinese population using health examination data.

Main Methods:

  • A retrospective cohort study of 65,517 participants aged 40+ in Ningbo, China.
  • LDL-C levels were categorized according to Chinese dyslipidemia guidelines.
  • Propensity-score weighting and Cox proportional hazard regression models were used to analyze mortality risks.

Main Results:

  • During follow-up, 2403 deaths occurred.
  • Extremely low LDL-C levels were associated with significantly higher risks of all-cause mortality (HR=2.53), cardiovascular disease (CVD) mortality (HR=1.84), ischemic stroke (HR=2.29), hemorrhagic stroke (HR=3.49), and cancer (HR=2.12).

Conclusions:

  • Low LDL-C levels are associated with an increased risk of all-cause mortality.
  • These findings suggest a link between very low LDL-C and higher risks of CVD, stroke subtypes, and cancer mortality in the studied Chinese population.
Abstract

Keywords:
CancerCardiovascular diseaseLDL-C0MortalityStroke

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