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Translational research in pediatric contrast-enhanced ultrasound

Anush Sridharan1, Misun Hwang2,3, Shelby Kutty4

  • 1Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA. sridharana@email.chop.edu.

Pediatric Radiology
|May 15, 2021
PubMed

Insights

Developing pediatric-specific preclinical models is crucial for advancing contrast-enhanced ultrasound (CEUS) imaging in children. These models ensure the safe and effective clinical translation of CEUS for pediatric applications.

Area of Science:

  • Medical Imaging
  • Pediatric Diagnostics
  • Ultrasound Technology

Background:

  • Contrast-enhanced ultrasound (CEUS) is a promising imaging modality.
  • Its application in pediatric populations requires specialized evaluation.
  • Current techniques are often adapted from adult protocols.

Purpose of the Study:

  • To develop and implement pediatric-specific preclinical models for CEUS evaluation.
  • To facilitate the clinical translation of CEUS for pediatric use.
  • To generate pediatric-specific data for this imaging technique.

Main Methods:

  • Development of dedicated pediatric animal models.
  • Creation of specialized phantom models for CEUS assessment.
  • Evaluation of CEUS performance using these preclinical models.

Main Results:

  • Successfully established and implemented pediatric-specific preclinical models.
  • These models are actively being used to evaluate CEUS.
  • The models are designed to support the clinical translation of CEUS to children.

Conclusions:

  • Pediatric-focused preclinical research is essential for advancing CEUS in children.
  • Developed animal and phantom models are key to this advancement.
  • These efforts aim to optimize CEUS for safe and effective pediatric clinical use.

Keywords:
ChildrenContrast-enhanced ultrasoundFetusNeonatesPhantomTranslational researchUltrasoundUltrasound contrast agents

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