A photoelectrochemical sensor based on Z-Scheme TiO₂@Au@CdS and molecularly imprinted polymer for uric acid detection

A novel photoelectrochemical (PEC) sensor based on "Z-scheme" TiO₂@Au@CdS and molecularly imprinted polymer (MIP) was developed for the non-invasive detection of uric acid (UA). The "Z-scheme" material, consisting of an electron-transfer system (Au) and two isolated photochemical systems (CdS, TiO₂), was synthesized by chemical deposition method and it worked as a substrate for electro-polymerization of MIP. Due to the high photoelectric conversion efficiency provided by TiO₂@Au@CdS and specific imprinting effect afforded by MIP, the sensor displayed desirable sensing performance with the merits of sensitivity, selectivity, repeatability, and stability. The linear range for UA detection is from 1 nM to 9 μM with the detection limit of 0.3 nM (S/N = 3). Moreover, the assay was successfully utilized to measure UA in human tears and offered a reliable result. The incorporation of MIP and "Z-scheme" material into a PEC sensor system is expected to provide a promising strategy for detecting other small molecules.