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Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex
T Sawaguchi1, M Matsumura, K Kubota
1Department of Neurophysiology, Kyoto University, Inuyama City, Aichi, Japan.
Neuroscience Research
|June 1, 1988
Abstract:
The influence of dopamine and its antagonists on neuronal activity related to the delay period of a delayed response task was examined in the monkey prefrontal cortex. Iontophoretically applied dopamine enhanced the delay-related neuronal activity, while fluphenazine and haloperidol attenuated the activity. Sulpiride had no effect on the activity. The results suggest that dopamine promotes processing of spatial short-term memory by increasing memory-related activity in the primate prefrontal cortex, probably via D1-type dopamine receptor.