Related Experiment Video

Updated: Nov 5, 2025

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells
07:12

Time-resolved Förster Resonance Energy Transfer Assays for Measurement of Endogenous Phosphorylated STAT Proteins in Human Cells

Published on: September 9, 2021

3.9K

STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in

Georgia Karpathiou1, Alexandra Papoudou-Bai2, Elise Ferrand1

  • 1Pathology Department, University Hospital of Saint-Etienne, France.

Pathology, Research and Practice
|May 15, 2021
PubMed

Insights

Signal Transducer and Activator of Transcription 6 (STAT6) is involved in allergic diseases and cancers. This review explores its role in pathology and diagnostic applications using immunohistochemistry.

Area of Science:

  • Immunology
  • Oncology
  • Pathology

Background:

  • Signal Transducer and Activator of Transcription 6 (STAT6) is activated by IL-4 and IL-13, promoting T helper type 2 (Th2) responses.
  • STAT6 dysregulation is linked to allergic conditions like asthma and atopic dermatitis.
  • The STAT6 pathway is implicated in tumor microenvironment regulation and certain lymphomas.

Purpose of the Study:

  • To review the pathophysiological implications of the STAT6 pathway.
  • To discuss the diagnostic and prognostic roles of STAT6 in pathology.
  • To cover immunohistochemical detection methods for STAT6.

Main Methods:

  • Literature review of STAT6's role in disease.
  • Analysis of STAT6's involvement in allergic conditions.
  • Examination of STAT6's function in oncogenesis and diagnostics.

Main Results:

  • STAT6 is a key factor in Th2-mediated allergic diseases.
  • STAT6 pathway dysregulation is observed in various lymphomas.
  • STAT6 immunohistochemistry is a diagnostic marker for solitary fibrous tumors.

Conclusions:

  • The STAT6 pathway has significant roles in allergic diseases and cancer.
  • STAT6 serves as a diagnostic and prognostic marker in specific pathologies.
  • Immunohistochemical detection of STAT6 is crucial for diagnosis.
Keywords:
AllergyImmunohistochemistryInflammationJAK-STATLymphomaMicroenvironmentSolitary fibrous tumorpSTAT6

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

593
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

587

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.8K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.8K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
8.1K
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
6.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K