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Microfluidic devices for multiplexed detection of foodborne pathogens
Xiaoying Han1, Yuanhui Liu1, Juxin Yin2
1Research Centre for Analytical Instrumentation, Institute of Cyber-Systems and Control, State Key Laboratory of Industrial Control Technology, Zhejiang University, Hangzhou 310023, PR China; College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China.
Food Research International (Ottawa, Ont.)
|May 16, 2021
Summary
Microfluidic devices offer rapid, portable, and multiplexed detection of foodborne pathogens. This review details sample preparation and detection methods for enhanced food safety on-site.
Area of Science:
- Food safety science
- Biotechnology
- Analytical chemistry
Background:
- Foodborne diseases pose a significant global health burden, primarily caused by foodborne pathogens.
- Current detection methods are evolving towards rapid, portable, inexpensive, and multiplexed on-site solutions.
- Microfluidics technology is crucial for developing sensitive and time-saving devices for on-site pathogen detection.
Purpose of the Study:
- To review sample preparation and detection methods on microfluidic devices for multiplexed foodborne pathogen detection.
- To provide a comprehensive understanding of cutting-edge technologies for food safety.
- To offer a comparative assessment for future in-field applications.
Main Methods:
- Detailed review of cell capture, enrichment, and nucleic acid sample preparation techniques on microfluidic platforms.
- Exhaustive illustration of detection methods including amplification, immunoassay, surface plasmon resonance, and impedance spectroscopy.
- Summarization and discussion of the limitations and advantages of various experimental options.
Main Results:
- Microfluidic devices enable simultaneous detection of multiple foodborne pathogens, enhancing food safety.
- Various sample preparation and detection strategies are available for microfluidic-based pathogen analysis.
- The review consolidates information on diverse microfluidic approaches for foodborne pathogen detection.
Conclusions:
- Microfluidics presents a promising platform for advanced, multiplexed on-site detection of foodborne pathogens.
- Further investigation and comparative assessment are needed for optimal in-field application of these technologies.
- The integration of sample preparation and detection methods on microfluidic chips is key to improving food safety surveillance.
