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Related Experiment Videos

"Proplast" for keratoprosthesis.

J H White1, O Gona

  • 1Department of Ophthalmology, UMDNJ-Robert Wood Johnson School of Medicine, Newark.

Ophthalmic Surgery
|May 1, 1988
PubMed
Summary
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A novel keratoprosthesis using Proplast, a Teflon composite, demonstrated successful long-term retention in rabbit corneas. This biomaterial shows promise for artificial cornea applications.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Polymer Science

Background:

  • Keratoprosthesis implantation is a surgical option for corneal blindness when transplantation fails.
  • Developing durable and biocompatible materials for artificial corneas remains a significant challenge.
  • Previous artificial cornea designs have faced issues with material degradation and host rejection.

Purpose of the Study:

  • To evaluate the biocompatibility and long-term retention of a novel keratoprosthesis design.
  • To assess the efficacy of a Proplast (Teflon fluorocarbon polymer and carbon fiber composite) support for polymethyl-methacrylate corneal implants.

Main Methods:

  • A keratoprosthesis incorporating a Proplast support and a polymethyl-methacrylate cylinder was designed.
  • The device was surgically implanted into the corneas of rabbit models.

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  • Implanted devices were monitored for retention, tissue integration, and adverse reactions over a period of up to 3 years.

    • Main Results:

    • The Proplast-supported keratoprosthesis achieved successful retention in rabbit corneas for up to 3 years.
    • No significant inflammatory responses or material degradation were observed during the study period.
    • The biomaterial composite demonstrated excellent biocompatibility with corneal tissues.

    Conclusions:

    • Proplast serves as a suitable and durable material for supporting artificial cornea implants.
    • This keratoprosthesis design shows potential for long-term clinical application in patients with severe corneal disease.
    • Further research is warranted to explore its use in human subjects.