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Small molecules targeting ubiquitination to control inflammatory diseases

Zheng-Qing Li1, Xiuping Chen1, Ying Wang2

  • 1Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine and, University of Macau, Avenida da Universidade, Taipa, Macao.

Drug Discovery Today
|May 16, 2021
PubMed

The ubiquitination and deubiquitination of proteins govern signal transduction in every aspect of physiology and pathology, especially in cancer, inflammation, and autoimmune diseases. Rapid progress has been made in obtaining an in-depth understanding of the ubiquitination system since its first discovery during the 1970s. Manipulation of ubiquitination by small molecules is considered a novel therapeutic avenue. In this review, we summarize key applications of small molecules targeting ubiquitination enzymes and currently available technologies applied to the discovery of small molecules that control ubiquitination.

Keywords:
Inflammatory diseasesSmall molecule modulatorUbiquitinUbiquitination system

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