Low-dose CT imaging via cascaded ResUnet with spectrum loss

The suppression of artifact noise in computed tomography (CT) with a low-dose scan protocol is challenging. Conventional statistical iterative algorithms can improve reconstruction but cannot substantially eliminate large streaks and strong noise elements. In this paper, we present a 3D cascaded ResUnet neural network (Ca-ResUnet) strategy with modified noise power spectrum loss for reducing artifact noise in low-dose CT imaging. The imaging workflow consists of four components. The first component is filtered backprojection (FBP) reconstruction via a domain transformation module for suppressing artifact noise. The second is a ResUnet neural network that operates on the CT image. The third is an image compensation module that compensates for the loss of tiny structures, and the last is a second ResUnet neural network with modified spectrum loss for fine-tuning the reconstructed image. Verification results based on American Association of Physicists in Medicine (AAPM) and United Image Healthcare (UIH) datasets confirm that the proposed strategy significantly reduces serious artifact noise while retaining desired structures.