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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Nov 5, 2025

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

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Management of dermatofibrosarcoma protuberans.

Arvind K Badhey1, Raisa Tikhtman, Alice L Tang

  • 1Department of Otolaryngology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Current Opinion in Otolaryngology & Head and Neck Surgery
|May 16, 2021
PubMed
Summary

Dermatofibrosarcoma protuberans (DFSP) is a challenging skin cancer with a high recurrence risk. Management involves surgery, with options like wide local excision or Mohs surgery, and systemic therapies for advanced cases.

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Area of Science:

  • Dermatology
  • Surgical Oncology
  • Cutaneous Sarcomas

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is an infiltrative cutaneous sarcoma.
  • DFSP characteristically presents as a slow-growing, asymptomatic skin lesion with a high risk of local recurrence but low risk of distant metastasis.

Purpose of the Study:

  • To provide an updated review of the diagnosis, workup, and treatment of DFSP.
  • To highlight comprehensive treatment strategies for managing this challenging disease.

Main Methods:

  • Review of current literature on DFSP diagnosis and management.
  • Discussion of surgical techniques including wide local excision (WLE) and Mohs surgery.
  • Evaluation of systemic therapies for unresectable DFSP.

Main Results:

  • DFSP exhibits deep local invasion and a high propensity for local recurrence, even with negative margins.
  • Wide local excision (WLE) and Mohs surgery are primary treatment modalities.
  • Systemic therapies, including imatinib, show promise for unresectable DFSP.

Conclusions:

  • Surgical management is the first-line treatment for DFSP, but lifelong surveillance is crucial due to high recurrence rates.
  • Recurrences typically occur within the first three years post-treatment.
  • Systemic and molecular targeted therapies are available for aggressive or unresectable DFSP.