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10 K: a large-scale prospective longitudinal study in Israel.
Smadar Shilo1,2,3, Noam Bar1,2, Ayya Keshet1,2
1Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
European Journal of Epidemiology
|May 16, 2021
Summary
The 10K study is building a large Israeli biobank to predict disease and find new molecular markers. This longitudinal cohort aims to improve diagnostics and therapeutics over 25 years.
Area of Science:
- Biomedical Research
- Epidemiology
- Biobanking
Background:
- The 10K study is a large-scale, prospective, longitudinal cohort and biobank established in Israel.
- Recruitment initiated in 2018, aiming for 10,000 participants aged 40-70 by 2021.
Purpose of the Study:
- Develop prediction models for disease onset and progression.
- Identify novel molecular markers with diagnostic, prognostic, and therapeutic value.
- Establish a comprehensive biobank for future research.
Main Methods:
- Recruited 4,629 participants between Jan 2019 and Dec 2020.
- Collected baseline data including medical history, lifestyle, anthropometrics, and various clinical tests (ECG, ABI, US, DXA).
- Performed extensive molecular profiling (transcriptome, proteome, microbiome, metabolome, immune system) and continuous monitoring (glucose, sleep).
Main Results:
- 46% of the target cohort recruited by December 2020.
- Comprehensive baseline data and molecular profiles collected from participants.
- Biobank established with stored blood and stool samples at -80°C.
Conclusions:
- The 10K cohort is a valuable resource for advancing disease prediction and biomarker discovery.
- Longitudinal data collection over 25 years will enable in-depth analysis of disease trajectories.
- Linkage with national registries will enhance the cohort's utility for public health research.
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