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Targeted α-therapy in non-prostate malignancies.

Hossein Jadvar1, Patrick M Colletti2

  • 1Division of Nuclear Medicine and Molecular Imaging Center, Department of Radiology, Keck School of Medicine of USC, University of Southern California, 2250 Alcazar St., CSC 102, Los Angeles, CA, 90033, USA. jadvar@med.usc.edu.

European Journal of Nuclear Medicine and Molecular Imaging
|May 16, 2021
PubMed
Summary

Targeted alpha-particle therapy (TAT) shows promise for various cancers beyond prostate. Research is expanding to new targets and alpha-emitters, validating TAT as a precision cancer management strategy.

Keywords:
AlphaCancerClinicalPreclinical

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Area of Science:

  • Oncology
  • Radiochemistry
  • Nuclear Medicine

Background:

  • Advances in cancer biology and radiochemistry enable targeted alpha-therapy (TAT).
  • The success of Radium-223 dichloride (²²³Ra) in prostate cancer highlights TAT's potential.
  • Research is exploring new alpha-emitters and biological targets for broader cancer applications.

Purpose of the Study:

  • To review preclinical and first-in-human studies of TAT in various malignancies.
  • To highlight the expanding scope of TAT beyond prostate cancer.
  • To discuss the future potential of TAT in precision cancer management.

Main Methods:

  • Review of preclinical research.
  • Analysis of first-in-human clinical trial data.
  • Synthesis of current data on targeted alpha-emitters and their biological targets.

Main Results:

  • TAT is being investigated for brain, breast, lung, gastrointestinal, pancreas, ovarian, and bladder cancers.
  • Studies also include leukemia, melanoma, myeloma, and neuroendocrine tumors.
  • Emerging data suggest TAT's safety and efficacy across diverse cancer types.

Conclusions:

  • Targeted alpha-therapy is a rapidly developing field with broad applicability in oncology.
  • Further research is needed to define and validate the role of TAT in various cancer treatments.
  • TAT represents an innovative approach to precision cancer management.