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Weight-reduction and changes in renal function in CKD patients participating in a conservative multimodal obesity
Clinical Nephrology
|May 17, 2021
Summary
Non-surgical obesity treatment significantly improved kidney function in patients with chronic kidney disease (CKD). This weight loss intervention offers a promising approach for managing obesity-related nephropathy (ORN) in obese CKD patients.
Area of Science:
- Nephrology
- Obesity Medicine
- Metabolic Diseases
Background:
- Obesity is a global epidemic, increasing interest in obesity-related nephropathy (ORN).
- Limited data exist on the long-term effects of conservative, non-surgical weight loss programs on renal function in patients with chronic kidney disease (CKD).
Purpose of the Study:
- To evaluate the impact of a 12-month non-surgical, multimodality obesity treatment program on renal function in obese patients with CKD.
Main Methods:
- Retrospective investigation of 17 obese patients with CKD (eGFR ≤ 60 mL/min/1.73m²).
- Patients participated in a non-surgical, multimodality obesity treatment program for 12 months.
- Renal function markers (serum creatinine, eGFR) and anthropometric data (weight, BMI) were assessed at baseline and 12 months.
Main Results:
- Significant average weight loss of -32.2 kg (p < 0.001) and BMI reduction (p < 0.001).
- Average serum creatinine decreased by 14.2 µmol/L (p = 0.004).
- Average eGFR increased by 14.8 mL/min (p = 0.002), indicating improved renal function.
Conclusions:
- A non-surgical, multimodal obesity intervention program can positively impact renal function in severely obese patients with CKD.
- Weight loss interventions are highly recommended for obese patients diagnosed with CKD.
- The study highlights the potential of conservative treatments in managing obesity-related kidney disease.
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