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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
Combined Pulmonary Fibrosis and Emphysema With Pulmonary Hypertension: Cases Report
Guillermo Cueto Robledo1, Merly Yamile Jurado Hernández1, Samuel Alejandro Gomez Lucas1
1Hospital General de México Dr. Eduardo Liceaga, Clínica de Hipertensión Pulmonar, Servicio de Neumología, Ciudad de México, México.
Background:
The combination of pulmonary fibrosis and emphysema (CPFE) has been recently defined as a syndrome, it is radiologically recognized and is characterized by the simultaneous coexistence of emphysema of superior pulmonary location and fibrosis predominantly in lower lobes.
Case Presentation:
We present three patients with CPFE, who underwent right cardiac catheterization for pulmonary hemodynamic assessment, finding mean pulmonary artery pressure (mPAP) between 37-52 mm Hg (mean 45 mm Hg), who received treatment with specific vasodilators for pulmonary arterial hypertension (PAH).
Discussion And Conclusions:
The three patients had higher mPAP than expected for Group III (Pulmonary hypertension due to lung disease and/or hypoxia) of the classification of pulmonary hypertension (PH) by the World Health Organization (WHO), in whom the use of Sildenafil was justified by the presence of progressive dyspnea, and no symptoms suggestive of infectious exacerbation associated with right ventricular failure.
