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Vaccinations and inflammatory bowel disease - a systematic review
Webber Chan1, Ennaliza Salazar1, Teong Guan Lim2
1Department of Gastroenterology and Hepatology, Singapore General Hospital Singapore.
Vaccination rates for patients with inflammatory bowel disease (IBD) are low due to poor knowledge and awareness. Gastroenterologists should lead vaccination efforts in IBD patients, as education shows variable success.
Area of Science:
- Immunology
- Gastroenterology
- Public Health
Background:
- Patients with inflammatory bowel disease (IBD) face increased infection risks, many preventable by vaccination.
- Systematic review focused on vaccination aspects in IBD patients.
Purpose of the Study:
- To systematically review vaccination rates, predictors, hesitancy reasons, and intervention outcomes in IBD patients.
- To identify barriers and facilitators for vaccination in this population.
Main Methods:
- Systematic literature search of PubMed and EMBASE databases up to January 31, 2021.
- Included 33 observational studies (146,918 patients).
- Data synthesized using medians, ranges, and narrative synthesis.
Main Results:
- Median vaccination rates for influenza, pneumococcal pneumonia, and hepatitis B were 42%, 20%, and 48%, respectively.
- Immunosuppression use, older age, and physician recommendations positively influenced vaccination rates.
- Lack of knowledge and awareness were key reasons for vaccine hesitancy among patients and physicians.
Conclusions:
- IBD patients exhibit suboptimal vaccination rates, similar to other chronic disease populations.
- Addressing knowledge gaps and enhancing awareness are crucial for improving vaccine uptake.
- Gastroenterologists should spearhead patient education and vaccination initiation in IBD care.
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