Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

17.6K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.6K
Cell Migration01:19

Cell Migration

5.6K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
5.6K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.1K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.1K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.7K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.7K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.1K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.1K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.9K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DySTrack - a modular smart microscopy tool for live tracking of dynamic samples on modern commercial microscopes.

Journal of cell science·2026
Same author

Force coordination distinguishes epithelial and mesenchymal modes of collective chemotaxis.

The Journal of cell biology·2026
Same author

Celebrating a century of the Spemann-mangold experiment: Self-organisation in biology.

Cells & development·2025
Same author

Neural Crest Migration Orchestrated by Molecular and Mechanical Signals.

Annual review of cell and developmental biology·2025
Same author

Forcing cell fate.

Nature cell biology·2025
Same author

Patterning in motion: Cell interfaces guide mesenchymal collective migration and morphogenesis.

The Journal of cell biology·2025
Same journal

Upregulation of adenylyl cyclase 1 is crucial for osteogenic and adipogenic differentiation of MSCs.

Cells & development·2026
Same journal

Toll-like receptors in epithelial mechanics and surveillance.

Cells & development·2026
Same journal

Functions and mechanisms of BRCA1 in early embryonic development.

Cells & development·2026
Same journal

The face you're born with: How early development dictates a lifetime of expression and ageing.

Cells & development·2026
Same journal

Inhibition of circNUP93 (hsa_circ_0039480) activates the IRS-1/Akt pathway and alleviates insulin resistance in gestational diabetes mellitus via the MiR-767-3p/HIF1A axis.

Cells & development·2026
Same journal

A comparative study of deep learning-based zebrafish image segmentation methods.

Cells & development·2026
See all related articles

Related Experiment Video

Updated: Nov 5, 2025

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.1K

Mechanosensitive ion channels in cell migration.

Brenda Canales Coutiño1, Roberto Mayor1

  • 1Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

Cells & Development
|May 17, 2021
PubMed
Summary
This summary is machine-generated.

Mechanosensitive (MS) ion channels detect mechanical forces, influencing cell migration. This review unifies the understanding of MS channels and their downstream calcium (Ca2+) signaling pathways in cell movement.

Keywords:
Calcium signallingCell migrationIon channelsMechanicsMechanotransduction

More Related Videos

Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.2K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.7K

Related Experiment Videos

Last Updated: Nov 5, 2025

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.1K
Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.2K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.7K

Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Cellular processes are regulated by mechanical stimuli.
  • Mechanosensitive (MS) ion channels are key cell membrane mechanosensors.
  • MS ion channels convert mechanical forces into cellular responses.

Purpose of the Study:

  • To review MS ion channel families regulating cell migration.
  • To analyze downstream molecular mechanisms, particularly Ca2+ signaling.
  • To propose future research directions in MS ion channel activity and cell migration.

Main Methods:

  • Literature review of MS ion channels and cell migration.
  • Analysis of Ca2+-mediated downstream signaling pathways.
  • Synthesis of current knowledge and identification of research gaps.

Main Results:

  • Several MS ion channel families are identified as regulators of cell migration.
  • Ca2+ influx through MS channels plays a crucial role in cell migration dynamics.
  • Downstream effectors of MS channel activation are diverse, impacting cell movement.

Conclusions:

  • MS ion channels are critical regulators of cell migration.
  • Understanding Ca2+ signaling downstream of MS channels is vital for cell migration research.
  • Further investigation into MS ion channels will impact developmental biology and cancer research.