Stepwise detoxification from cocaine. A promising regimen

Cocaine dependence may not respond to behavioral and self-help treatment because of alterations in neurochemistry, particularly the catecholamine system. Thus, medical detoxification using a stepwise approach and several different therapeutic agents is often needed to assist the patient in achieving a cocaine-free state. An outpatient regimen includes regular clinic attendance, urine testing, education of patient and family, psychological evaluation, and a three- to four-week counseling program. Continued use of medication may be advisable for four to six months. Re-treatment is encouraged if relapse occurs.