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Updated: Nov 5, 2025

Ex Vivo Optogenetic Dissection of Fear Circuits in Brain Slices
Published on: April 5, 2016
Inhibitory Circuits in the Basolateral Amygdala in Aversive Learning and Memory
Madhusoothanan B Perumal1, Pankaj Sah1,2,3
1Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Abstract:
Neural circuits in the basolateral amygdala (BLA) play a pivotal role in the learning and memory formation, and processing of emotionally salient experiences, particularly aversive ones. A diverse population of GABAergic neurons present in the BLA orchestrate local circuits to mediate emotional memory functions. Targeted manipulation of GABAergic neuronal subtypes has shed light on cell-type specific functional roles in the fear learning and memory, revealing organizing principles for the operation of inhibitory circuit motifs in the BLA.
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