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An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury
Published on: December 31, 2017
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Revascularization After Traumatic Spinal Cord Injury.
Chun Yao1, Xuemin Cao1, Bin Yu1
1Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, China.
Frontiers in Physiology
|May 17, 2021
Summary
Traumatic spinal cord injury (SCI) triggers secondary damage, disrupting blood vessels and causing inflammation. Revascularization therapies aim to repair these damaged vessels for improved SCI recovery.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Vascular Biology
Background:
- Traumatic spinal cord injury (SCI) involves initial mechanical damage followed by a secondary injury cascade.
- SCI disrupts local microvasculature and blood-spinal cord barriers, leading to inflammation and tissue damage.
- Endogenous angiogenesis post-SCI is insufficient and often results in non-functional new blood vessels.
Purpose of the Study:
- To describe vascular system alterations and their effects on the local microenvironment after SCI.
- To summarize current revascularization therapies for treating spinal cord injury.
Main Methods:
- Review of literature on vascular changes following SCI.
- Summary of various therapeutic interventions targeting revascularization in SCI.
Main Results:
- SCI causes significant damage to the microvasculature and impairs blood-spinal cord barrier integrity.
- While angiogenesis is initiated, it is often inadequate for functional recovery.
- Multiple therapeutic strategies, including growth factor administration, gene modulation, cell transplantation, biomaterials, and physical stimulation, have been explored.
Conclusions:
- Understanding vascular alterations in SCI is crucial for developing effective treatments.
- Revascularization therapies hold promise for mitigating secondary injury and promoting functional recovery after spinal cord injury.
