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Severity of COVID-19 and Treatment Strategy for Patient With Diabetes

Shi Jin1, Weina Hu2

  • 1Department of Endocrinology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.

Frontiers in Endocrinology
|May 17, 2021
PubMed

Insights

This review examines how diabetes and its comorbidities impact COVID-19 severity. It highlights the need for targeted therapeutic strategies for diabetic patients facing SARS-CoV-2 infection.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) rapidly became a global pandemic.
  • Patients with comorbidities like diabetes face higher risks of severe COVID-19 symptoms and mortality.
  • The specific role of diabetes, its comorbidities, and treatments in COVID-19 prognosis remains unclear.

Purpose of the Study:

  • To review existing evidence on potential risk factors for severe COVID-19 in diabetic patients.
  • To identify gaps in current understanding regarding diabetes and COVID-19 outcomes.
  • To explore the need for novel therapeutic strategies for SARS-CoV-2 in individuals with diabetes.

Main Methods:

  • Systematic review of existing scientific literature.
  • Analysis of clinical trial data on glucose-lowering agents.
  • Evaluation of reported COVID-19 cases with pre-existing diabetes.

Main Results:

  • Diabetes and associated conditions are linked to increased COVID-19 severity and mortality.
  • Current treatment protocols for COVID-19 in diabetic patients are not standardized.
  • Further research is needed to elucidate the complex interplay between diabetes and SARS-CoV-2.

Conclusions:

  • Understanding the risk factors is crucial for managing COVID-19 in diabetic populations.
  • Development of specific therapeutic interventions for diabetic COVID-19 patients is urgently required.
  • Addressing the unique challenges faced by diabetic individuals during the pandemic is essential.

Keywords:
COVID-19Diabetes mellitusSARS-CoV-2cytokine stormglycemic control

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