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Insulin Signaling in Arthritis
Cesare Tripolino1, Jacopo Ciaffi2, Valentina Pucino3
1Geriatric Medicine Unit, Department of Medical Functional Area, "San Giovanni di Dio" Hospital, Crotone, Italy.
Frontiers in Immunology
|May 17, 2021
Summary
Inflammatory arthritis increases metabolic disorders like insulin resistance. This review explores the two-way link between impaired insulin signaling and arthritis, impacting immune responses and disease progression.
Area of Science:
- Immunometabolism
- Rheumatology
- Endocrinology
Background:
- Inflammatory arthritis is linked to metabolic disorders, including insulin resistance, diabetes, and hyperlipidemia.
- The relationship between arthritis and metabolic abnormalities is increasingly recognized as bidirectional.
- Immune cells express the insulin receptor (IR), suggesting a direct role for insulin signaling in immune function.
Purpose of the Study:
- To review the bidirectional relationship between impaired insulin signaling and inflammatory arthritis.
- To analyze how insulin signaling influences aberrant immune responses in arthritis.
- To examine the impact of inflammatory mediators on insulin signaling and the efficacy of glucose-lowering agents in arthritis.
Main Methods:
- Literature review focusing on immunometabolism and arthritis.
- Analysis of studies investigating insulin receptor function in immune cells (T cells, macrophages).
- Synthesis of evidence on the interplay between inflammatory mediators and insulin signaling pathways.
Main Results:
- Absence of IR in T-cells reduces cytokine production, proliferation, and migration in murine models.
- Defective insulin signaling in macrophages enhances glycolysis and affects pathogen response.
- Inflammatory mediators can impair insulin signaling, contributing to metabolic dysfunction in arthritis.
Conclusions:
- Impaired insulin signaling plays a significant role in the aberrant immune responses characteristic of inflammatory arthritis.
- Inflammation associated with arthritis negatively impacts insulin signaling, exacerbating metabolic disorders.
- Understanding this bidirectional relationship is crucial for developing targeted therapies for arthritis and associated metabolic complications.
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