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Advances in cancer treatment: a new therapeutic target, Annexin A2

Zinan Li1,2, Lifeng Yu1,2, Baohui Hu1,2

  • 1Department of Pharmacology, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang City, 110122, Liaoning, China.

Journal of Cancer
|May 17, 2021
PubMed

Insights

Annexin A2 (ANXA2) shows promise as a biomarker for cancer diagnosis and prognosis. Targeting ANXA2 offers potential for novel cancer therapies, with early preclinical results suggesting clinical translation feasibility.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Annexin A2 (ANXA2) is a calcium-regulated phospholipid-binding protein.
  • ANXA2 is expressed in tumor cells, endothelial cells, macrophages, and mononuclear cells.
  • Aberrant ANXA2 expression is implicated in cell survival and intercellular/extracellular microenvironment interactions.

Purpose of the Study:

  • To review the diagnostic and prognostic potential of ANXA2 in progressive cancers.
  • To explore restorative interventions targeting ANXA2 in cancer treatment.
  • To comment on ANXA2-targeted therapies for clinical translation.

Main Methods:

  • Review of existing literature on ANXA2 in cancer.
  • Analysis of preclinical studies using various technologies to target ANXA2.
  • Discussion of ANXA2's role in cancer diagnosis, prognosis, and therapy.

Main Results:

  • ANXA2 expression can serve as a predictive factor, diagnostic biomarker, and therapeutic target in cancer.
  • Preclinical models targeting ANXA2 have shown encouraging results.
  • ANXA2's latent capacity in progressive cancers is significant.

Conclusions:

  • ANXA2 holds considerable potential as a biomarker for cancer diagnosis and prognosis.
  • Targeting ANXA2 represents a promising strategy for novel cancer therapeutics.
  • Further research into ANXA2-targeted therapies could lead to clinical translation.
Keywords:
Annexin A2cancercancer therapytarget

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