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Related Experiment Video

Updated: Nov 5, 2025

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

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Markerless Liver Tumor Localization Using Internal Liver Volume Delineated By Four-Dimensional Cone-Beam CT.

Naohisa Mizukami1, Kiyoshi Yoda2

  • 1Department of Radiation Oncology, Yame General Hospital, Yame, JPN.

Cureus
|May 17, 2021
PubMed
Summary

Markerless liver tumor localization is feasible using four-dimensional cone-beam CT (4D CBCT) to delineate internal liver volumes. This method accurately guides radiation therapy by accounting for liver movement during the respiratory cycle.

Keywords:
4d cbctfour-dimensional cone-beam computed tomographyigrtimage guided radiotherapyinternal liver volumelipiodolliver tumorlocalizationmarkerless

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Area of Science:

  • Medical Physics
  • Radiotherapy Oncology
  • Medical Imaging

Background:

  • Accurate liver tumor localization is crucial for effective radiotherapy.
  • Traditional methods may require invasive markers.
  • Four-dimensional cone-beam CT (4D CBCT) offers a non-invasive imaging solution.

Observation:

  • A novel markerless liver tumor localization technique was developed using 4D CBCT.
  • Internal liver volumes were delineated on planning CT and 4D CBCT data.
  • The gross target volume (GTV) was expanded based on liver motion observed during the respiratory cycle.

Findings:

  • The proposed markerless method demonstrated high accuracy, comparable to lipiodol-based techniques.
  • Target localization deviations were minimal: 0.7 mm (lateral), 2.0 mm (superior-inferior), and -2.1 mm (anterior-posterior).
  • Feasibility was confirmed through analysis of 25 treatment fractions.

Implications:

  • This markerless approach enhances the precision and safety of liver radiotherapy.
  • It reduces the need for invasive markers, improving patient comfort and reducing potential complications.
  • The technique provides a robust framework for image-guided adaptive radiotherapy for liver tumors.