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Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer

Toshihiko Takeiwa1, Kazuhiro Ikeda1, Kuniko Horie-Inoue1

  • 1Division of Systems Medicine & Gene Therapy, Saitama Medical University, Saitama, Japan.

Frontiers in Cell and Developmental Biology
|May 17, 2021
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate apoptosis in ovarian cancer cells. Understanding these mechanisms offers new therapeutic targets for this common gynecological malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ovarian cancer is a leading cause of gynecological cancer mortality worldwide.
  • Late diagnosis due to subtle early symptoms often leads to poor prognosis.
  • There is a critical need for novel diagnostic and therapeutic strategies.

Purpose of the Study:

  • To review recent findings on the molecular mechanisms of apoptosis-related long non-coding RNAs (lncRNAs) in ovarian cancer.
  • To highlight the role of lncRNAs in regulating apoptosis evasion in ovarian cancer cells.
  • To explore the potential of lncRNAs as therapeutic targets.

Main Methods:

  • Literature review of recent studies on lncRNAs and apoptosis in ovarian cancer.
  • Analysis of molecular mechanisms involving lncRNAs in regulating apoptosis.
  • Synthesis of information on transcription factors, histone modification, miRNAs, and protein stability.

Main Results:

  • Long non-coding RNAs (lncRNAs) are implicated in the regulation of apoptosis in ovarian cancer cells.
  • Mechanisms include modulation of transcription factors, histone modifications, microRNAs (miRNAs), and protein stability.
  • Dysregulation of apoptosis contributes to tumor progression and therapeutic resistance.

Conclusions:

  • Apoptosis regulatory mechanisms mediated by lncRNAs represent promising targets for ovarian cancer therapy.
  • Further research into lncRNA function can lead to improved diagnostic and treatment strategies.
  • Targeting lncRNAs may overcome therapy resistance in advanced ovarian cancers.
Keywords:
apoptosiscompeting endogenous RNAhistone modification complexlong non-coding RNAovarian cancerovarytranscriptional regulation

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