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Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Updated: Nov 5, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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Serum Complement C1q Activity Is Associated With Obstructive Coronary Artery Disease.

Shuren Guo1, Xiaohuan Mao2, Xiaohua Li1

  • 1Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Frontiers in Cardiovascular Medicine
|May 17, 2021
PubMed
Summary

Serum complement C1q activity is elevated in patients with obstructive coronary artery disease (CAD). Higher C1q levels correlate with increased risk of CAD and restenosis after revascularization, indicating its association with obstructive CAD.

Keywords:
Gensini scorenon-obstructive CADobstructive CADrestenosisserum complement C1q

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Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarker Discovery

Background:

  • Complement C1q has a complex role in atherosclerosis, with prior studies yielding inconsistent findings on its association with coronary artery disease (CAD).
  • This study aimed to clarify the relationship between serum C1q activity and CAD, including stenosis severity, cardiovascular biomarkers, and restenosis risk.

Purpose of the Study:

  • To investigate the association between serum complement C1q activity and the presence and severity of obstructive and non-obstructive CAD.
  • To explore the correlation of C1q activity with cardiovascular biomarkers and 1-year restenosis rates post-revascularization.

Main Methods:

  • A cohort of 956 CAD patients and 677 controls were analyzed.
  • Serum C1q activity and various laboratory markers were measured.
  • Statistical analysis was performed using SPSS22.0.

Main Results:

  • Serum C1q activity was significantly higher in both obstructive and non-obstructive CAD groups compared to controls.
  • Increased C1q activity correlated with higher total cholesterol and triglyceride levels.
  • C1q activity was linked to an increased risk of CAD and 1-year restenosis, but not Gensini score after adjustments.

Conclusions:

  • Serum complement C1q activity is associated with obstructive CAD.
  • Elevated C1q activity may serve as a predictive marker for restenosis after coronary revascularization.