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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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Serum Complement C1q Activity Is Associated With Obstructive Coronary Artery Disease

Shuren Guo1, Xiaohuan Mao2, Xiaohua Li1

  • 1Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Frontiers in Cardiovascular Medicine
|May 17, 2021
PubMed

Insights

Serum complement C1q activity is elevated in patients with obstructive coronary artery disease (CAD). Higher C1q levels correlate with increased risk of CAD and restenosis after revascularization, indicating its association with obstructive CAD.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biomarker Discovery

Background:

  • Complement C1q has a complex role in atherosclerosis, with prior studies yielding inconsistent findings on its association with coronary artery disease (CAD).
  • This study aimed to clarify the relationship between serum C1q activity and CAD, including stenosis severity, cardiovascular biomarkers, and restenosis risk.

Purpose of the Study:

  • To investigate the association between serum complement C1q activity and the presence and severity of obstructive and non-obstructive CAD.
  • To explore the correlation of C1q activity with cardiovascular biomarkers and 1-year restenosis rates post-revascularization.

Main Methods:

  • A cohort of 956 CAD patients and 677 controls were analyzed.
  • Serum C1q activity and various laboratory markers were measured.
  • Statistical analysis was performed using SPSS22.0.

Main Results:

  • Serum C1q activity was significantly higher in both obstructive and non-obstructive CAD groups compared to controls.
  • Increased C1q activity correlated with higher total cholesterol and triglyceride levels.
  • C1q activity was linked to an increased risk of CAD and 1-year restenosis, but not Gensini score after adjustments.

Conclusions:

  • Serum complement C1q activity is associated with obstructive CAD.
  • Elevated C1q activity may serve as a predictive marker for restenosis after coronary revascularization.

Keywords:
Gensini scorenon-obstructive CADobstructive CADrestenosisserum complement C1q

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