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Increased Urinary CD163 Levels in Systemic Vasculitis with Renal Involvement

Xiayire Aierken1, Qing Zhu1, Ting Wu1

  • 1Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang 830001, China.

Biomed Research International
|May 17, 2021
PubMed

Insights

Urinary CD163 levels are elevated in systemic vasculitis patients, particularly those with kidney involvement. This suggests urinary CD163 may serve as a biomarker for systemic vasculitis and associated renal complications.

Area of Science:

  • Nephrology
  • Immunology
  • Rheumatology

Background:

  • Systemic vasculitis involves inflammation of blood vessels and can lead to severe hypertension.
  • CD163 is a specific marker for anti-inflammatory macrophages.

Purpose of the Study:

  • To evaluate CD163 levels in patients with systemic vasculitis.
  • To assess the relationship between CD163 levels and renal involvement in systemic vasculitis.

Main Methods:

  • Retrospective analysis of urinary CD163 levels using ELISA.
  • Comparison of CD163 levels in 51 systemic vasculitis patients, 42 essential hypertension patients, and 36 healthy controls.
  • Correlation analysis between urinary CD163 and clinical indicators.

Main Results:

  • Urinary CD163 levels were significantly higher in systemic vasculitis patients compared to controls and essential hypertension patients.
  • Patients with renal involvement showed markedly elevated urinary CD163 levels.
  • Urinary CD163 levels correlated positively with markers of kidney function (serum creatinine, BUN) and beta-2 microglobulin.
  • Granulomatous vasculitis subtypes exhibited higher CD163 levels than necrotizing vasculitis.

Conclusions:

  • Urinary CD163 is significantly elevated in systemic vasculitis, especially with renal involvement.
  • Urinary CD163 demonstrates potential as a diagnostic biomarker for systemic vasculitis with renal complications.
Abstract

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