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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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Bioinspired Polymeric High Aspect Ratio Particles with Asymmetric Janus Functionalities.

Joel A Finbloom1, Yiqi Cao1, Tejal A Desai1

  • 1Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, 204 Byers Hall, 1700 4 Street, San Francisco, CA 94158 USA.

Advanced Nanobiomed Research
|May 17, 2021
PubMed
Summary

Researchers developed novel Janus high aspect ratio particles (J-HARPs) inspired by bacteriophage. These bioinspired particles offer precise control over surface functionalization for advanced biomedical applications.

Keywords:
Janusbioconjugationbioinspired materialsbiotinnanotechnologyparticlepolymer

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Regenerative Medicine

Background:

  • Developing polymeric particles with asymmetric functionalities is crucial for applications in regenerative medicine, tissue engineering, and drug delivery.
  • Existing Janus particles are often spherical, non-biocompatible, and require specialized fabrication.
  • There is a need for nonspherical, biocompatible Janus particles with controlled functionalization.

Purpose of the Study:

  • To fabricate nonspherical Janus particles inspired by filamentous bacteriophage using polycaprolactone.
  • To achieve regioselective biofunctionalization on these high aspect ratio Janus particles (J-HARPs).
  • To demonstrate the utility of J-HARPs in targeted delivery and spatially controlled bioconjugation.

Main Methods:

  • Fabrication of J-HARPs using a nanotemplating technique to create branching morphologies.
  • Modification of J-HARPs with maleimide handles for subsequent biomolecule conjugation.
  • Functionalization with proteins and biotin to assess regioselective modification and targeting capabilities.

Main Results:

  • Successful fabrication of J-HARPs with selective branching morphologies.
  • Demonstrated regioselective modification at the branching regions of J-HARPs.
  • Biotinylated J-HARPs showed cancer cell targeting and directional crosslinking; dual-labeled J-HARPs exhibited spatially separated bioconjugation.

Conclusions:

  • J-HARPs represent a new class of bioinspired Janus materials.
  • These particles offer excellent regional control over biofunctionalization.
  • J-HARPs hold promise for advanced applications in targeted drug delivery and tissue engineering.