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Serial analysis of fibronectin concentration in sera from septic patients
R Bălună1, R Tarnavschi, D Barac
1Department of Immunology, V. Babes Institute, Bucharest, Romania.
Medecine Interne
|January 1, 1988
Abstract:
Serum fibronectin (Fn) level was serially determined in nineteen septic patients. Fn concentration was found significantly decreased in septic patients (mean +/- SE, 120 +/- 11 micrograms/ml) as compared to the control (205 +/- 11 micrograms/ml). The decrease of Fn was correlated with the severity of sepsis; it was persistent and more important in severe septic cases. The lowest Fn concentration was found in nonsurviving patients (78 +/- 18 micrograms/ml). Serum Fn level may reflect the degree of organ failure and predict the evolution of sepsis.