[Research progress of in vivo bioreactor for bone tissue engineering]

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Orthopedic Surgery

Background:

• Traditional bone tissue engineering faces challenges with vascularization.
• The in vivo bioreactor (IVB) leverages the body's regenerative capacity.
• IVB offers a potential solution for creating vascularized bone grafts.

Purpose of the Study:

• To review the research progress of in vivo bioreactors (IVB) in bone tissue engineering.
• To provide insights into future research directions for IVB technology.
• To summarize the principles, methods, and advantages of IVB for bone regeneration.

Main Methods:

• Literature review of recent studies on IVB in bone tissue engineering.
• Analysis of IVB construction principles, tissue types, and surgical techniques.
• Summary of the advantages of using IVB for bone tissue engineering.

Main Results:

• IVB utilizes the body's regenerative potential to create vascularized tissue engineered bone.
• IVB can be constructed using various tissue flaps and vascular pedicles.
• Prefabricated bone grafts from IVB can repair bone defects, addressing vascularization limitations.

Conclusions:

• IVB is a promising method for vascularized bone tissue engineering, especially for large defects.
• Complexity and surgical complications currently limit clinical application of IVB.
• Future research should prioritize developing simpler, safer, and more efficient IVB techniques.